The French midfielder, often used in defence by Madrid, was replaced in the squad by Jacobo Ramon and Chema Andres for the home match that kicks off at 1515 GMT.
Los Blancos are a point behind La Liga leaders Atletico Madrid, who lost 1-0 on Saturday at Leganes. Real host RB Salzburg in a crucial Champions League game on Wednesday.
© Agence France-Presse